Spike Postdoctoral Research Papers on International Frontier Journals
Release time:
2022-06-01
Recently, good news came from the postdoctoral workstation of Jianfeng Pharmaceutical. Under the guidance of workstation mentor Jiang Xiaomeng, associate researcher Yang Xiaoxiao has made new progress in the treatment of alcoholic liver disease. The relevant research results "Roxadustat , A hypoxia-inducible factor 1a activator, attenuates both long- and short-term alcohol induced alcoholic liver disease was published in the internationally renowned academic journal" Frontiers in Pharmacology . This journal is a frontier journal in the field of international pharmacy, mainly publishing academic papers and information on basic and clinical pharmacology, medicinal chemistry, pharmacology and toxicology.
Alcoholic liver disease is one of the main types of liver disease in the world. Its pathogenesis includes the initial alcoholic fatty liver, which further evolves into alcoholic steatohepatitis, and even liver fibrosis and cirrhosis. It may deteriorate into liver cancer, and the pathogenesis is more complex, which has always been a hot topic in academic research. Previous academic research on alcoholic liver disease mainly focused on lipid metabolism disorders, alcohol-induced inflammatory infiltration, oxidative stress in liver cells, and intestinal microbial disorders. The research results of Yang Xiaoxiao and others focused on the new role of the chronic kidney disease anemia treatment drug roxaldostat in alcoholic liver disease. The therapeutic effect of roxaldostat was explored by constructing acute and chronic alcoholic liver disease models, and combined with cell experiments to verify the therapeutic effect. The results show that alcohol can cause lipid metabolism disorders, and also cause inflammation, oxidative stress and other adverse effects in the liver. Roxastat increases fatty acid oxidation by inhibiting the expression of lipid synthesis genes SREBP1c , ChREBP , FASN , ACC1 , DGAT1 , and promoting PPAR ; roxalustat can also reduce the accumulation of macrophages and the release of proinflammatory cytokines to improve the inflammatory process; roxalustat reduces the expression of CYP2E1 and promotes superoxide dismutase SOD1 , which can alleviate the oxidative stress caused by alcohol. The above studies show that roxalustat can be used as a potential treatment for alcoholic liver disease.
The research was supported by the China Postdoctoral Science Foundation and the Zhejiang Provincial Postdoctoral Program. Gao Yongyao and Yang Daigang, graduate students of Hefei University of Technology, are the co-first authors, and Yang Xiaoxiao, associate researcher, is the corresponding author.
More information
Jianfeng International Trade Selected as Pilot Enterprise of Non-car Carrier Logistics
In August, Jianfeng International Trading Company successfully passed the evaluation of traffic management departments and expert groups in Zhejiang Province and Jinhua City, and was successfully selected as a pilot enterprise of car-free carrier logistics in Zhejiang Province in 2019. "Car-free transportation" is a new format in the logistics industry brought about by the widespread application of information Internet technology. The "car-free carrier" signs a transportation contract with the shipper as a carrier, assumes the responsibilities and obligations of the carrier, and entrusts the actual carrier to complete the transportation task. Road freight operators. Compared with the traditional concept of logistics mode, car free carrier has the characteristics of strong resource integration ability, wide brand effect and obvious network effect. It is of great significance to promote the intensive integration of resources and the standardized development of the freight market by using Internet means and organizational mode innovation, which is of great significance to promote the transformation and upgrading of the logistics freight industry and improve the quality and efficiency. The planning and construction objectives of the "car-free carrier" platform envisaged by Jianfeng International Trade are: based on the influence of the peak region and the advantages of integrating qualification resources, changing the competition mode, expanding the market coverage and profit pattern, and realizing the transformation and upgrading of traditional businesses, I .e. realizing the "five" operations of PDCA closed-loop operation of supply chain system and marketing marketization, coordination of transportation capacity, customization of services, platform datalization and de-intermediation, we will continue to promote the regional logistics market from low, small, scattered and empty to resource sharing, value sharing and win-win cooperation, and finally build an integrated supply chain service system of "logistics Internet post-market finance. The relevant person in charge of the peak international trade said that the "car-free carrier" pilot qualification, for the peak international trade to change the business model, improve the quality of service.
2020
07-31
Peak International Trade Won Cotton Yarn Delivery Warehouse Qualification
On August 2, Zhengzhou Commodity Exchange issued "on the establishment of a new designated cotton yarn delivery warehouse and the announcement of the water", the peak international trading company officially obtained the Zheng Shang designated delivery warehouse qualification. According to the amendment to the cotton yarn futures business rules announced by Zheng Shang in March, the social warehouse delivery method will be introduced on the basis of retaining the original factory warehouse delivery, and will take the lead in implementing it in Shandong, Henan, Jiangsu and Zhejiang. As one of the eight new warehouse delivery units after the amendment is issued, Jianfeng International Trade can carry out cotton yarn futures delivery business from September 2019. Lanxi City, a subsidiary of Jinhua, is a "famous weaving city in China" and a national textile industry base. It has more than 1000 textile enterprises and an annual demand for cotton yarn of more than 1 million tons. After Jianfeng International Trade obtains the qualification for cotton yarn futures delivery, it can not only provide cotton yarn futures delivery sites for Lanxi cotton textile industry and upstream and downstream merchants, but also effectively serve Jinhua counties and cities, Xiaoshan, Shaoxing, Quzhou, Wenzhou and other places, and other provinces, and Fujian provinces. Since Jianfeng International Trade became a futures delivery warehouse in 2009, it has carried out four types of business of Dalian Commodity Exchange PVC, PE, PP and plywood. Cotton yarn delivery is the company's first business variety in Zhengzhou Commodity Exchange. At present, Jianfeng International Trade is actively organizing learning and training on cotton yarn business knowledge, actively expanding business channels, and understanding the actual needs of upstream and downstream industries to ensure the operation, service quality and delivery efficiency of this new business. (Huang Zhiyu)
2020
07-31
Peak International Trade Won Cotton Yarn Delivery Warehouse Qualification
On August 2, Zhengzhou Commodity Exchange issued "on the establishment of a new designated cotton yarn delivery warehouse and the announcement of the water", the peak international trading company officially obtained the Zheng Shang designated delivery warehouse qualification. According to the amendment to the cotton yarn futures business rules announced by Zheng Shang in March, the social warehouse delivery method will be introduced on the basis of retaining the original factory warehouse delivery, and will take the lead in implementing it in Shandong, Henan, Jiangsu and Zhejiang. As one of the eight new warehouse delivery units after the amendment is issued, Jianfeng International Trade can carry out cotton yarn futures delivery business from September 2019. Lanxi City, a subsidiary of Jinhua, is a "famous weaving city in China" and a national textile industry base. It has more than 1000 textile enterprises and an annual demand for cotton yarn of more than 1 million tons. After Jianfeng International Trade obtains the qualification for cotton yarn futures delivery, it can not only provide cotton yarn futures delivery sites for Lanxi cotton textile industry and upstream and downstream merchants, but also effectively serve Jinhua counties and cities, Xiaoshan, Shaoxing, Quzhou, Wenzhou and other places, and other provinces, and Fujian provinces. Since Jianfeng International Trade became a futures delivery warehouse in 2009, it has carried out four types of business of Dalian Commodity Exchange PVC, PE, PP and plywood. Cotton yarn delivery is the company's first business variety in Zhengzhou Commodity Exchange. At present, Jianfeng International Trade is actively organizing learning and training on cotton yarn business knowledge, actively expanding business channels, and understanding the actual needs of upstream and downstream industries to ensure the operation, service quality and delivery efficiency of this new business. (Huang Zhiyu)
2020
07-30
Peak International Trade Won Cotton Yarn Delivery Warehouse Qualification
On August 2, Zhengzhou Commodity Exchange issued "on the establishment of a new designated cotton yarn delivery warehouse and the announcement of the water", the peak international trading company officially obtained the Zheng Shang designated delivery warehouse qualification. According to the amendment to the cotton yarn futures business rules announced by Zheng Shang in March, the social warehouse delivery method will be introduced on the basis of retaining the original factory warehouse delivery, and will take the lead in implementing it in Shandong, Henan, Jiangsu and Zhejiang. As one of the eight new warehouse delivery units after the amendment is issued, Jianfeng International Trade can carry out cotton yarn futures delivery business from September 2019. Lanxi City, a subsidiary of Jinhua, is a "famous weaving city in China" and a national textile industry base. It has more than 1000 textile enterprises and an annual demand for cotton yarn of more than 1 million tons. After Jianfeng International Trade obtains the qualification for cotton yarn futures delivery, it can not only provide cotton yarn futures delivery sites for Lanxi cotton textile industry and upstream and downstream merchants, but also effectively serve Jinhua counties and cities, Xiaoshan, Shaoxing, Quzhou, Wenzhou and other places, and other provinces, and Fujian provinces. Since Jianfeng International Trade became a futures delivery warehouse in 2009, it has carried out four types of business of Dalian Commodity Exchange PVC, PE, PP and plywood. Cotton yarn delivery is the company's first business variety in Zhengzhou Commodity Exchange. At present, Jianfeng International Trade is actively organizing learning and training on cotton yarn business knowledge, actively expanding business channels, and understanding the actual needs of upstream and downstream industries to ensure the operation, service quality and delivery efficiency of this new business. (Huang Zhiyu)
2020
07-31
Peak International Trade Won Cotton Yarn Delivery Warehouse Qualification
On August 2, Zhengzhou Commodity Exchange issued "on the establishment of a new designated cotton yarn delivery warehouse and the announcement of the water", the peak international trading company officially obtained the Zheng Shang designated delivery warehouse qualification. According to the amendment to the cotton yarn futures business rules announced by Zheng Shang in March, the social warehouse delivery method will be introduced on the basis of retaining the original factory warehouse delivery, and will take the lead in implementing it in Shandong, Henan, Jiangsu and Zhejiang. As one of the eight new warehouse delivery units after the amendment is issued, Jianfeng International Trade can carry out cotton yarn futures delivery business from September 2019. Lanxi City, a subsidiary of Jinhua, is a "famous weaving city in China" and a national textile industry base. It has more than 1000 textile enterprises and an annual demand for cotton yarn of more than 1 million tons. After Jianfeng International Trade obtains the qualification for cotton yarn futures delivery, it can not only provide cotton yarn futures delivery sites for Lanxi cotton textile industry and upstream and downstream merchants, but also effectively serve Jinhua counties and cities, Xiaoshan, Shaoxing, Quzhou, Wenzhou and other places, and other provinces, and Fujian provinces. Since Jianfeng International Trade became a futures delivery warehouse in 2009, it has carried out four types of business of Dalian Commodity Exchange PVC, PE, PP and plywood. Cotton yarn delivery is the company's first business variety in Zhengzhou Commodity Exchange. At present, Jianfeng International Trade is actively organizing learning and training on cotton yarn business knowledge, actively expanding business channels, and understanding the actual needs of upstream and downstream industries to ensure the operation, service quality and delivery efficiency of this new business. (Huang Zhiyu)
2020
07-22
Peak Pharmaceuticals Ranked "Top 100 Chinese Drugs"
From July 15 to 18, the National Pharmacy Week and China Pharmaceutical Innovation and Development Conference was held in Jinan, Shandong Province. The conference released the "2018 China Pharmaceutical Industry Top 100 Series List". Zhejiang Jianfeng Pharmaceutical Co., Ltd. ranked 74th in the "TOP100 List of Chinese Pharmaceutical Enterprises. The "2018 Top 100 Series List of Chinese Pharmaceutical Industry" is divided into five sub-lists: "TOP100 List of Chinese Pharmaceutical Enterprises", "TOP100 List of Chinese Traditional Medicine Enterprises", "TOP20 List of Chinese CRO (including CDMO) Enterprises", "TOP20 List of Chinese Medical Devices (including IVD) Enterprises" and "TOP20 List of Chinese Biomedicine (including Blood Products, Vaccines, Insulin, etc.) Enterprises. The "chemical pharmaceutical enterprise" in the "TOP100 list of Chinese pharmaceutical enterprises" refers to the enterprises whose terminal sales of chemical drugs account for more than 51% of the total terminal income of the enterprises. The selection score consists of two parts, one is the innovation driving force of the enterprise, that is, the R & D comprehensive index score of R & D investment in 2018, accounting for 40% of the weight; The second is the professional promotion power of the enterprise, that is, the terminal quantitative data determined by the final selection needs of clinicians and patients in 2018, accounting for 60% of the weight; the objects participating in the selection are pharmaceutical industry enterprises registered in China (excluding subsidiaries of multinational pharmaceutical enterprises in China) and whose main business is pharmaceutical manufacturing. The convening of the conference and the release of the list have received widespread attention from the industry. Relevant leaders of the state and Shandong Province attended the meeting, chief scientist of Peak Pharmaceutical, Chinese Academy of Engineering
2020
07-31
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