Daily accumulation is the cornerstone of paving the road to success
Release time:
2021-03-12
Pharmaceutical Company 2020 Outstanding Scientific and Technological Worker Pharmaceutical Company Product Development Department Liu Yang
I have been engaged in the research and development of bulk drugs since I entered the company in 2013 . I cherish the title of "Tech Worker " , because to have technology is to have the power of innovation, to create unlimited possibilities. Therefore, as workers in the pharmaceutical industry, we must have a pattern that is in line with the domestic first-class pharmaceutical companies, and we must also dare to establish the ideal of catching up with the world's advanced level of medicine. We have the responsibility and ability to make technological breakthroughs become an important force in the development of our enterprises. After so many years of research and development work, I know very well that the nature of scientific and technological work requires the accumulation of a lot of basic work, repeated verification and attention to details, and finally qualitative changes can be caused by quantity.
Looking back on the past year, it was full and full of difficulties and challenges. Last year, it was notified in January 19 that the National Evaluation Center would conduct on-site verification of the esomeprazole sodium project we declared in February 21 4 . However, the process of raw materials has not been verified on the modified equipment. It only took more than 3 months and the Spring Festival holiday in the middle. We only had the chance to find problems in production in batch 1 trial production. We used batch 2 to verify the feasibility of the production plan. Batch 4 as the on-site dynamic verification batch must be safe. During the trial production, there were many problems, such as excessive impurities in the products and blocking materials during the preparation of intermediates. It can be said that the operation of the trial production process was not smooth, and the quality of the products obtained was not good. As soon as the trial production is over, we will summarize all the problems in time and analyze the reasons step by step. For example, the impurity exceeding the standard is due to the key process of the project: the reaction conditions required for oxidation reaction are relatively harsh, and the new equipment in the workshop cannot do experiments like in the laboratory, and the temperature control and feeding are very accurate. While we were discussing how to increase the ability of equipment control through small improvements, we were thinking hard about other countermeasures, and the on-site operator said: "This side of the fine process is simply not suitable for large-scale production! " This sentence made me suddenly realize that I used to think that the more detailed and accurate the process, the better, but now it seems to be a misunderstanding. Because if the operating parameters of a process are very accurate, every production should be more careful, which will undoubtedly increase the risk of production failure. However, if the parameters of the process are in a very wide range, the operator can ensure the product quality as long as he follows the relevant procedures and does not need very fine operation. Of course, the process with wide parameters is better. Therefore, with this idea in mind, I came back to consult the literature, read the summary of previous experiments, analyzed the reaction conditions of the oxidation process one by one, and proved my idea through 10 batch of small-scale experiments. After that, the conditions for the oxidation reaction were appropriately relaxed, and at the same time, with the improvement of equipment, in the following batches of production, the key process was basically stable, impurities were controllable, and the reaction law was clear.
In addition, the problem of intermediate blocking the pipeline occurred during the trial production, which not only affected the quality and yield of the product, but also increased the difficulty of the production operation. A simple crystallization rejection and filtration process can be completed in normal2 hours, and our trial production took more than 8 hours. This intermediate itself is easy to agglomerate quickly. We have many methods to deal with agglomeration in the laboratory trial production process, but it is completely impossible to enlarge the production. If this difficult problem is not solved, the on-site verification will definitely fail. In the face of this problem, I pondered hard for a few days. The experimental phenomena that I had done before kept flashing in my mind. It suddenly occurred to me that this intermediate had a very short forming period when it was separated out. The key to solving the agglomeration lies in this short forming period. It hasn't come out earlier, and it has already formed hard lumps if it is later, so when I do this step of production, I will keep a close eye on the forming time. As soon as the forming period arrives, I will immediately increase the stirring speed and cooperate with the impact of the air flow to prevent the material from forming hard lumps. Finally, after 2 batch production attempts, the problem was successfully solved and the production cycle was greatly shortened.
Through the concerted efforts of various departments, esomeprazole sodium successfully passed the on-site dynamic inspection in4 and the compliance inspection of GMP in 11 , and successfully obtained the production license. In addition to the esomeprazole sodium project, last year I also did a lot of work for the verification of imatinib mesylate application, which ensured the smooth progress of the verification production now.
shared so much, I think as a scientific and technological worker, we should not only have lofty ideals and firm confidence, but also pay attention to basic work, be patient and not let go of details. Ideal and confidence are like road signs, and the accumulation of daily work is the cornerstone of paving the road to success. The two complement each other and are indispensable. Only in this way can we truly achieve"to set up a peak ambition and make a high-quality medicine " , turn our work into an important part of promoting the development of the company and grow together with the enterprise.
(according to Liu Yang's speech at the summary commendation meeting of the pharmaceutical company)
More information
The company's vocational skill level self-identification training began.
After preparing the handout materials and question bank for the previous stage of vocational skill grade identification training, daye peak cement company conducted the vocational skill grade identification training for the machine repair team of the manufacturing department on August 10. On August 12 and 18, the pharmaceutical company also organized two phases of vocational skill level identification training for pharmaceutical preparation workers. According to the national skill level standard, the group company is divided into four grades: grade 5/junior worker, grade 4/intermediate worker, grade 3/senior worker and grade 2/technician. According to the analysis of employee registration, since there is only one type of job for pharmaceutical preparation workers, and cement production workers include cement central controller, cement quality inspector, cement clinker calciner, cement manufacturer, cement production inspection worker and other types of jobs, the number of applicants is less than that of cement production workers. Most of the employees who signed up were identified as participating in the four levels of vocational skills. According to preliminary statistics, there are now 155 employees who have signed up for their professional skill level, including 47 pharmaceutical preparation workers and 108 cement production workers. The human resources department of the group company is stepping up efforts to organize personnel to examine the qualifications of the employees whose registration grades are identified, and then enter the Zhejiang professional ability integration platform for formal registration after passing the examination. According to the national vocational skill standards and other content, each unit carries out targeted training for employees who participate in the independent identification of vocational skill levels. The training is conducted through on-site teaching, online teaching, and learning platform question bank exercises. After the training, the group company will organize the employees who participate in the grade identification to carry out examination and assessment, and those who pass the examination will complete the grade identification and issue the skill grade certificate. It is understood that in order to ensure the quality of vocational skill level identification, after the company was approved to independently identify the vocational skill level, the human resources department of the group organized all units to compile the question bank for various types of work in combination with the actual situation of the enterprise and with reference to the national vocational skill standards and training syllabus and other materials. after classification, unification and standardization, verification and proofreading, the preparation of the question bank has been basically completed. After being submitted to the superior unit for examination and approval, the company will import the question bank on the enterprise university platform to facilitate employees to prepare for the examination. The question bank for the independent identification of vocational skills level will also be extracted from the question banks of various industries, including professional ethics, basic knowledge, safety and environmental protection knowledge, laws and regulations knowledge, professional work practice and other national vocational skills standards. Basic requirements. The examination and assessment for independent determination of vocational skill level is tentatively scheduled for mid-September.
2021
08-23
Hu Guoyun, vice mayor of Pu'er, visited the peak
On July 16, a delegation led by Hu Guoyun, vice mayor of Pu'er City, Yunnan Province, and heads of Pu'er SASAC, Industrial Park Management Committee, Investment Promotion Bureau and other departments visited the headquarters of the group company. In the exchange with Jiang Xiaomeng, Yu Jianhong and other group leaders, Hu Guoyun expressed his gratitude to Jianfeng Group on behalf of the Pu'er Municipal Party Committee and Municipal Government. He said that the investment and entrepreneurship from Jianfeng to Pu'er not only promoted the development of Pu'er's regional industrial economy, but also made outstanding contributions to the local poverty alleviation. The two sides also exchanged and discussed issues such as strengthening in-depth cooperation between the two sides.
2021
07-21
Municipal SASAC Party Committee Visited Jianfeng Old Party Member
On June 28, Huang Zunhui, a second-level researcher of the State-owned Assets Supervision and Administration Commission of Jinhua City, visited Jianfeng Group and made a special trip to visit two retired party members, Chen Bingxiang and Yin Rongfu. Among the two Jianfeng veteran party members, Chen Bingxiang has been engaged in party affairs for nearly 30 years, and Yin Rongfu has won the honor of outstanding party members in Zhejiang Province and is a representative of Jianfeng party workers and party members. On behalf of the party committee of the Municipal State-owned assets Supervision and Administration Commission, Huang Zunhui expressed condolences to the two veteran party members, thanked the older generation of party members for their contributions, and exchanged views with Jiang Xiaomeng, secretary of the party committee and chairman of the group, and Qin Xuping, member of the party committee and chairman of the trade union, and fully affirmed the development of peak in recent years and the improvement of the level of party building work.
2021
07-12
"I'll teach you a lesson." Concluded successfully.
On the afternoon of June 24, as one of the highlights of the company's 2021 safety production month series of activities, the second phase of the "I'll give you a lesson" safety training was held at the group headquarters. the management personnel, production backbones and personnel from all departments and offices of the group gathered at the scene. foreign enterprises took safety "big lessons" through video, which was more effective than the teaching. At this point, the "I'll give you a lesson" safety training has come to a successful conclusion.
2021
07-12
Glory in the Party's 50-year-old Party Member Xi Ling Commemorative Medal
On June 23, the party committee of the group company sent a special person to visit and awarded the commemorative medals of "50 years of Glory in the Party" to six veteran party members. 2021 is the 100 anniversary of the founding of the Communist Party of China. For the first time, the Party Central Committee issued the "50 Years of Glory in the Party" commemorative medal to surviving party members who have reached the 50th anniversary of the party and have always performed well. The Organization Department of the Central Committee also specially issued the "Administrative Measures for the Issuance of Commemorative Medals of" Glory in the Party for 50 Years "", which stipulates the issuance procedures, issuance methods, production, and management of commemorative medals. In the future, the "50 Years of Glory in the Party" commemorative medal will be issued as a regular task and will be issued once every year around July 1.
2021
07-12
What is the exact time of the first Congress of the Communist Party of China? Which "big" representatives boarded the red boat in South Lake? What is the connection between the 1972 Sino-US Joint Communique and Hangzhou? On the morning of June 24th, the Party Committee of the Group Company invited members of the Party History Learning and Education Group of Zhejiang Provincial Party Committee and the vice president of Zhejiang Branch of China News Service to give a special party class of "returning to the scene of party history and reappearing the moment of party history" for the party members and cadres of the Company.
2021
07-01
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