Shanghai Bronze Award for Outstanding Invention Went in North Carolina
Release time:
2020-07-22
Shanghai Excellent Invention Bronze Award Went to North Carolina
News The results of the 31 Shanghai Excellent Invention Trial jointly organized by Shanghai Federation of Trade Unions, Shanghai Intellectual Property Office, Shanghai Municipal Committee of the Communist Youth League, Shanghai Science and Technology Association and Shanghai Invention Association were selected a few days ago, shanghai Beika Pharmaceutical Technology Co., Ltd. declared "Erlotinib Hydrochloride and Its Advanced Intermediate Quality Improvement and Industrialization Optimization " won the bronze award.
erlotinib hydrochloride is a targeted therapeutic drug for the treatment of non-small cell lung cancer, which can prolong the survival time and improve the quality of life of lung cancer patients. It can target and specific action sites to kill tumor cells, and has little impact on normal tissues. It belongs to the biological and new medical technology in the field of high-tech supported by the state. In this invention, 6,7- dimethoxyquinazoline -4- ketone, 4- chlorine -6,7- bis (2- methoxyethoxy) quinazoline and 3- aminophenylacetylene are important intermediates of erlotinib hydrochloride, the latter is also an important intermediate of icotinib hydrochloride, the first new anti-tumor drug in China. The invention designs and adopts a new synthesis process route, which can effectively reduce the cost of raw materials, the reactions are mostly aqueous phase reactions, the energy consumption and three waste emissions are reduced by about 35% , the industrialization conditions are optimized, the product quality is improved, and it is applied to industrial mass production, which is conducive to the production of high-quality and low-cost erlotinib hydrochloride drugs and the economic burden of patients is reduced.
Shanghai Excellent Invention Contest was founded in 1987 . It is an important scientific and technological award approved by the Shanghai Municipal Government. It not only strongly promotes the majority of employees to carry out invention and creation activities based on their posts, but also improves the unit's independent innovation ability. Taking this award as an opportunity, Shanghai North Carolina will further focus on small molecule chemical innovative drugs and characteristic chemical intermediates, continue to build a high-level technology platform around the key links of new drug research and development, and cultivate scientific and technological innovation teams. (Fang Yuyu)
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