Shanghai Bronze Award for Outstanding Invention Went in North Carolina
Release time:
2020-07-31
News from this newspaper The results of the 31 Shanghai Excellent Invention Trial jointly organized by the Shanghai Federation of Trade Unions, the Shanghai Intellectual Property Office, the Shanghai Municipal Committee of the Communist Youth League, the Shanghai Science and Technology Association, and the Shanghai Invention Association were evaluated a few days ago, shanghai Beika Pharmaceutical Technology Co., Ltd. declared "Erlotinib Hydrochloride and Its Advanced Intermediate Quality Improvement and Industrialization Optimization " won the bronze award.
erlotinib hydrochloride is a targeted therapeutic drug for the treatment of non-small cell lung cancer, which can prolong the survival time and improve the quality of life of lung cancer patients. It can target and specific action sites to kill tumor cells, and has little impact on normal tissues. It belongs to the biological and new medical technology in the high-tech field supported by the state. In this invention, 6,7- dimethoxyquinazoline -4- ketone, 4- chlorine -6,7- bis (2- methoxyethoxy) quinazoline and 3- aminophenylacetylene are important intermediates of erlotinib hydrochloride, the latter is also an important intermediate of icotinib hydrochloride, the first new anti-tumor drug in China. The invention designs and adopts a new synthesis process route, which can effectively reduce the cost of raw materials, the reactions are mostly aqueous phase reactions, the energy consumption and three waste emissions are reduced by about 35% , the industrialization conditions are optimized, the product quality is improved, and it is applied to industrial mass production, which is conducive to the production of high-quality and low-cost erlotinib hydrochloride drugs and the economic burden of patients is reduced.
Shanghai Excellent Invention Contest was founded in 1987 . It is an important scientific and technological award approved by the Shanghai municipal government. It not only strongly promotes the majority of employees to carry out invention and creation activities based on their posts, but also improves the independent innovation ability of the unit. Taking this award as an opportunity, Shanghai North Carolina will further focus on small molecule chemical innovative drugs and characteristic chemical intermediates, continue to build a high-level technology platform around the key links of new drug research and development, and cultivate scientific and technological innovation teams. (Fang Yuyu)
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