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Behind the Luck.

Release time:

2020-08-14

"Luck"

Artificial Bezoar Workshop Reconstruction Documentary

After four months of intense work, 8# September 9 , the artificial bezoar technical renovation project of Qiubin Factory was successfully completed, 8 18 , 19 , 20 , the trial production of the first three batches of products was successfully completed. Yi Shengrong, director of the Akihama Factory, lamented, "We are lucky this time".

Good luck, this is of course a joke. To do such a big project well, luck alone is of course not enough. What really plays a decisive role is the seriousness and hard work of the project team members.

Pharmaceutical Company has many years of successful experience in producing artificial bezoar, but from the beginning of the project transformation, due to the use of raw materials, production process, process standards, and production scale are almost different, so the previous experience is not for them. Help, can only be explored from scratch through the efforts of participating construction personnel. From the beginning of the

project, the project team was formed by Yi Shengrong, director of Qiubin Factory, Yu Chengfeng, production technology department, Yan Xixia, workshop director, Fang Weiming, mechanic, and Tang Songnian, electrician. While ensuring normal production, the project began to transform. The civil engineering project of workshop

started in March 4 . The project team members divided their work according to their own fields. Fang Weiming and Tang Songnian, who were responsible for equipment selection, went to many equipment manufacturers to understand relevant information, make comparisons and prepare for bidding. Compared with the previous production, the requirements for environmental protection are higher now. When designing the artificial bezoar workshop, it was decided to adopt dust-free transportation. All equipment is connected through pipelines. In order to meet this requirement, most equipment must be customized from the manufacturer. Before the formal bidding of the equipment, the project team also held a special meeting to brainstorm and put forward opinions and suggestions on equipment selection according to the collected information and their own work experience. It has been suggested that corn starch is one of the main raw materials for the production of artificial bezoar. A lot of heat will be generated during the ball milling process. If the temperature is too high, the starch will stick together and affect the quality of the product. Although there is no requirement for this in the process standard, it can be related to the quality of the product, so when selecting the equipment, the equipment manufacturer is required to increase the cooling system for the heat dissipation problem of the ball mill. Fang Weiming said that it takes three months for general equipment manufacturers to obtain orders and provide products, but we only have more than one month, and the equipment is not stereotyped, so the two sides have communicated repeatedly many times.

Despite this, there were still some small "episodes" in the acceptance stage before the equipment entered the site ". There is a gap between the inlet and outlet of the equipment and the previous requirements, which will cause waste of raw materials. But because the construction period is very tight, the time nodes of each link are very close, if you can not enter the site on time, the whole project will be affected. This can be anxious for the project team. After communication and arrangement, it was finally decided to give the equipment manufacturer a week to revise it. After meeting the required requirements, the equipment was pulled over quickly. Other minor problems can only be to let the equipment manufacturer personnel come over and make on-site modifications.

In the trial production stage, in order to save costs, Qiubin Factory decided that the batch of products is 100 kg, while the design capacity of the equipment is 500 kg. There is no data that can be directly referred to for the process parameters such as ball mill speed, ball milling time and ball quantity. Before the trial, the members of the project team also consulted relevant production enterprises, however, the other party has only tried batch 300 kg, and has not succeeded. There are more than ten kinds of trial production schemes involved in the three parameters. Time and cost are not allowed to try multiple schemes. We can only rely on the collection and selection of indirect experience collected by project team members from various channels, and finally confirm the formation of the scheme decided to put into production. The trial production was an unexpected success. All the indexes of the three batches of trial production products passed the test. Moreover, the color, the most difficult index to control for artificial bezoar, was highly recognized by the sales agent.

The implementation of the whole project is relatively smooth, and there may be elements of luck, but behind this "luck", only the participants know how much effort and hardship they have put in. Cleaning the workshop equipment happens to be the hottest time. The weather has been more than 40 degrees for more than half a month, which makes the project team members unable to bear it. The workshop that has just been renovated is very dusty, but in order to ensure the cleaning quality, the air conditioner cannot be turned on, so it can only be cleaned under high temperature. Once out of the workshop, the whole person seems to have been soaked in water, and none of his body is dry. Moreover, his body is covered with dust. If there is something to do in the production workshop, he has to change clothes first.

Yan Xixia was impressed by one thing. The proportion and amount of balls in the ball mill will directly affect the product quality. For this reason, the two employees put 4 alumina balls of different sizes, totaling 2 tons, into small baskets one by one, and poured them into the ball mill with their bare hands for testing. The ball mill is large in size, and the feed port is above the machine. Employees holding the ball have to walk on a platform more than two meters high before they can pour in. If the ratio is not right, it has to be poured out again, cleaned, dried, and then poured in baskets again. This data alone has been tried for 3. four days. It goes up and down dozens of times a day. It is completely a physical job. Sometimes my hands shake after work. And sometimes afraid of miscounting the number of balls, employees squat down directly one by one.

Not only that, during the entire construction period from 4 to 7 February, Yu Chengfeng, Fang Weiming and Tang Songnian did not rest for a day and gave up their holidays. As long as the construction unit was present, they would have to be there. Finally, even the number of overtime days was not counted.

The end of the three batches of trial production products does not mean the end of this technological transformation project. They have a more important task, that is, to apply for GMP certification, and are now preparing for relevant materials. (Reporter Ni Yingzhen)

More information

Shanghai Bronze Award for Outstanding Invention Went in North Carolina

News from this newspaper The results of the 31st Shanghai Excellent Invention Trial jointly organized by the Shanghai Federation of Trade Unions, Shanghai Intellectual Property Office, Shanghai Municipal Committee of the Communist Youth League, Shanghai Science and Technology Association, and Shanghai Invention Association were evaluated a few days ago. The "Quality Improvement and Industrialization Optimization of Erlotinib Hydrochloride and Its Advanced Intermediates" declared by Technology Co., Ltd. won the bronze award. Erlotinib hydrochloride is a targeted therapy drug for the treatment of non-small cell lung cancer, which can prolong the survival time and improve the quality of life of lung cancer patients. It can target and specific sites of action to kill tumor cells, and has little impact on normal tissues. It belongs to the biological and new medical technology in the field of high-tech supported by the state. In this invention, 6,7-dimethoxyquinazoline -4-one, 4-chloro -6,7-di (2-methoxyethoxy) quinazoline and 3-aminophenylacetylene are important intermediates of erlotinib hydrochloride, which is also an important intermediate of icotinib hydrochloride, the first new anti-tumor drug of tinib in China. The invention designs and adopts a new synthesis process route, which can effectively reduce the cost of raw materials, the reactions are mostly aqueous phase reactions, energy consumption and three waste emissions are reduced by about 35%, industrialization conditions are optimized, product quality is improved, and it is applied to Industrialized mass production is conducive to the production of high-quality and low-cost erlotinib hydrochloride drugs and reduces the economic burden of patients. The Shanghai Excellent Invention Trial was founded in 1987. It is an important science and technology award approved by the Shanghai Municipal Government. It not only strongly promoted the majority of employees to carry out invention and creation activities based on their posts, but also improved the order.

2020

07-31

Jiang Xiaomeng Selected as Top Ten News Figures in Building Materials Industry Interview with China Building Materials Magazine in August

Jiang Xiaomeng was selected as one of the top ten news figures in the building materials industry. "China Building Materials" magazine published an exclusive interview in August. The 8th issue of 2019 "China Building Materials" magazine published a few days ago. In the "Exclusive Perspective" column, it published an exclusive interview with Jiang Xiaomeng, the top ten news figures in the building materials industry in 2018, the party secretary and chairman of the group company. The selection of the top ten news figures in the national building materials industry initiated by "China Building Materials" magazine has established nearly a hundred shining figures in the industry since 1999, which has attracted widespread attention in the industry. The selection of the top ten news figures in the building materials industry in 2018 is described as follows: Jiang Xiaomeng is a scholar and practical outstanding entrepreneur. In 2018, with his strategic thinking of insight into the future, he united and led cadres and employees at all levels of Jianfeng Group to actively adapt to the new economic normal, focusing on deepening supply-side structural reforms, the "Belt and Road" initiative, and vigorously advocating corporate transformation and upgrading and high-quality development. Work, seize opportunities, reform and innovate, and achieve historic new achievements in the development of the peak 60 years. The group's overall economic efficiency and development quality have been significantly improved. In recent years, under the leadership of Jiang Xiaomeng, Jianfeng Group has seized the opportunity to join forces with central enterprises to participate in the establishment of Southern Cement, effectively integrate the cement market in Zhejiang Province, optimize the allocation of cement industry resources, and greatly improve social and economic benefits. It has a positive and far-reaching impact on the supply-side structural reform and healthy development of the cement industry in Zhejiang Province. At the same time, the long-term layout of the peak group, strategically predict the direction of national development.

2020

07-31

To live up to the mission and realize the dream of a century-Jiang Xiaomeng, Party Secretary and Chairman of Zhejiang Jianfeng Group Co., Ltd., Top Ten News Figures in Building Materials Industry in 2018

Jianfeng Group started from a small cement plant with an annual output of 30000 tons in 1958. Through horizontal alliance with township enterprises, the formation of enterprise groups and the implementation of joint-stock reform, Jianfeng Group took the lead in listing in China's cement industry in 1993 and explored diversified operation. In 2007, Jianfeng joined hands with the central enterprise China Building Materials to participate in the establishment of Southern Cement, which strategically shifted the focus of the cement industry, and at the same time through enterprise mergers and technological innovation, the pharmaceutical industry is growing rapidly ...... Such a long history, in the industry has a good reputation of enterprises, Zhejiang Province, the earliest existing listed companies, its head is Jiang Xiaomeng. Focus on Industry Jiang Xiaomeng has spent nearly 40 years in Jinhua Cement Factory, the predecessor of Jianfeng Group. As a witness and promoter of the development and growth of the peak, Jiang Xiaomeng said that the sustained and steady development of the peak group benefits from the long-term focus on industry, which is the value orientation of the peak and the responsibility of the enterprise. Whether there was only a single cement industry in the early stage or the diversified development after listing, all the investment projects of the peak have not left the industry. With the continuous emergence of new economic formats, many people once suggested that the peak should be transferred to the "fashionable" and rewarding industries such as the Internet, but they were all rejected. Jiang Xiaomeng explained that it is necessary to use professional people to do professional things. Peak's years of experience, talents, and resource accumulation are all in industry. Although the new format is good, it is not necessarily suitable for peak development. Take cement as an example, even in the case of peak pharmaceutical has occupied the group.

2020

07-31

Jiang Xiaomeng Selected as Top Ten News Figures in Building Materials Industry Interview with China Building Materials Magazine in August

2020

07-31

Jiang Xiaomeng Selected as Top Ten News Figures in Building Materials Industry Interview with China Building Materials Magazine in August

2020

07-30

The company held the first half of the board of directors, the board of supervisors half-year performance hit a record high

On August 29, the group company held the 11th meeting of the 10th board of directors of the company by means of communication, and deliberated and passed the semi annual report of Jianfeng group in 2019 and the amendment of internal control system of the company. In the first half of the year, the company focused on the general work policy of "innovation and reform, integration and improvement, scientific layout, and steady development", grasping the opportunities brought by economic structure optimization and industrial upgrading externally, continuously integrating resources internally, and improving the internal management system. Improve the efficiency of enterprise operation. In the first half of 2019, the company achieved total operating income of 1.686 billion billion yuan, an increase of 12.17 percent over the same period last year, and the net profit attributable to the owners of the parent company was 0.476 billion billion yuan, an increase of 57.55 percent over the same period last year. At the end of June 2019, the Company's total assets were $5.383 billion, up 9.82 from the beginning of the year, and its net assets were $3.817 billion, up 10.64 from the beginning of the year. In the first half of the year, the company made a new breakthrough in the expansion of cement business. The group company has completed the acquisition of 100 equity of Guizhou huangpinggu longmingchuan cement co., ltd. and continues to invest in the construction of its new dry cement production line with a daily output of 4500 tons of cement clinker (with waste heat power generation). Yunnan Jianfeng invested 5 million yuan to participate in the establishment of Yunnan Jianfeng Da Zhan Cement Co., Ltd., which plans to build a cement clinker production line in lameng county, Xishuangxian Dai autonomous prefecture by capacity replacement according to relevant national policies. The company's cement subsidiaries continue to carry out in-depth "three down three improve" activities, stable.

2020

07-31

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